Rein A, Henderson L E, Levin J G
Retroviral Genetics Section, NCI-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA.
Trends Biochem Sci. 1998 Aug;23(8):297-301. doi: 10.1016/s0968-0004(98)01256-0.
Retrovirus particles contain a small, basic protein, the nucleocapsid (NC) protein, that possesses 'nucleic acid chaperone' activity--that is, the NC protein can catalyze the rearrangement of a nucleic acid molecule into the conformation that has the maximal number of base pairs. The molecular mechanism that underlies this effect is not understood. Because the chaperone activity is apparently crucial during the infectious process, NC is a potential target for antiviral therapy.
逆转录病毒颗粒含有一种小的碱性蛋白质，即核衣壳（NC）蛋白，它具有“核酸伴侣”活性——也就是说，NC蛋白可以催化核酸分子重排为具有最大碱基对数量的构象。这种效应背后的分子机制尚不清楚。由于伴侣活性在感染过程中显然至关重要，因此NC是抗病毒治疗的一个潜在靶点。
