Miller I, Cerná J, Trávnícek J, Rejnek J, Kruml J
Folia Microbiol (Praha). 1975;20(5):433-8. doi: 10.1007/BF02877048.
The protective effect of pig immune colostrum, serum and immunoglobulins IgG, IgM and IgA against the enterotoxic strain of Escherichia coli O55, was studied in newborn germfree piglets. This strain produced accumulation of fluid and dilatation of intestine when injected into the ligated ileal segment of germfree piglets, which is considered to be the typical effect of enterotoxins. Erosion of the intestinal epithelium and penetration of bacteria into the submucosa were also observed. Immune serum, colostrum and all the immunoglobulin classes used produced a local protective effect, IgA being most effective. The mechanism of protection conferred by these immunoglobulins is discussed with respect to the possible pathogenic action of enterotoxic Escherichia coli O55 in the intestinal tract of immunologically virgin germfree piglets.
在新生无菌仔猪中研究了猪免疫初乳、血清以及免疫球蛋白IgG、IgM和IgA对大肠杆菌O55肠毒素菌株的保护作用。将该菌株注射到无菌仔猪的结扎回肠段时，会导致液体蓄积和肠道扩张，这被认为是肠毒素的典型作用。还观察到肠道上皮的糜烂以及细菌渗透到黏膜下层。免疫血清、初乳和所有使用的免疫球蛋白类别均产生局部保护作用，其中IgA最为有效。针对免疫初免的无菌仔猪肠道中肠毒素性大肠杆菌O55可能的致病作用，讨论了这些免疫球蛋白的保护机制。
