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[某些躁狂抑郁症病例染色体生物学结构的长期分析(作者译)]

[The long-range analysis of the chrombiological structure of some cases of manic-depressive illness (author's transl)].

作者信息

Sipprian U

出版信息

Fortschr Neurol Psychiatr Grenzgeb. 1975 Nov;43(11):575-601.

PMID:1104450
Abstract

Within the group of endogenous psychoses manic-depressive illness is a subgroup which can be explicitly described. The psychopathologic phenomena of their current status (Momentagefüge) are disorders of drive and mood. The time structure generally exhibits the characteristic sequence of acute phases and "free" intervals, while in detail there are numerous variations of intensity, such as siurnal variation of mood etc. An essential of the definition of endogenous psychoses has always been their periodicity. However, in the majority of cases that periodicity was not conclusively proved. On the basis of one representative case factor analyses of a long and complete series of daily self-rating scales were performed. A dichotomy of time series of mood scores and of drive scores was used for autocorrelation. Thereby two different multiday periods were established. Two periods of this type combine to produce an interferential period, which does not generally occur on a continual scale, but only in a systematic selection. This was the subject of investigation. From 100 phase schedules (Phasenkalender) of manic-depressive psychoses 18 cases with long periods were selected by means of a special technique of cross-correlation, which were re-analyzed under methodologically more stringent conditions. Such re-analyses confirmed the initial hypothesis. The entire phase schedule is composed of interferential periods...

摘要

在内源性精神病组中,躁郁症是一个可以明确描述的亚组。其当前状态(当下组合)的精神病理现象是驱力和情绪障碍。时间结构通常呈现急性期和“缓解”期的特征性序列,而在细节上,强度有许多变化,如情绪的昼夜变化等。内源性精神病定义的一个要点一直是其周期性。然而,在大多数情况下,这种周期性并未得到确凿证明。基于一个代表性案例,对一系列长期完整的每日自评量表进行了因素分析。情绪评分和驱力评分的时间序列二分法用于自相关分析。由此确定了两个不同的多日周期。这两种类型的周期结合产生一个干扰周期,它一般不是连续出现,而是仅在系统选择中出现。这就是研究的主题。通过一种特殊的互相关技术,从100份躁郁症精神病的阶段时间表中选出18例周期较长的病例,并在方法上更严格的条件下重新进行分析。这样的重新分析证实了最初的假设。整个阶段时间表由干扰周期组成……

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