Kemp B, Winkler M, Rath W
Department of Obstetrics and Gynecology, Technical University Hospital of Aachen, Aachen, Germany.
Int J Gynaecol Obstet. 2000 Oct;71(1):13-7. doi: 10.1016/s0020-7292(00)00253-8.
To compare the effectiveness of prostaglandin E(2) intravaginal gel with the intracervical gel in patients with an unfavorable cervix.
In a prospective multicenter trial 470 patients with unfavorable Bishop scores (3-4) were randomized to receive prostaglandin vaginal gel (2 mg) or intracervical gel (0.5 mg).
In patients with unfavorable Bishop scores the intravaginal application route resulted in a better cervical ripening, a shorter induction to delivery interval and a higher cumulative rate of deliveries during 24 h (P=0.01).
Intravaginal instillation of prostaglandin E(2) gel for induction of labor is effective in patients with an unfavorable Bishop score of 3-4.
比较前列腺素E₂阴道凝胶与宫颈内凝胶对宫颈条件不佳患者的疗效。
在一项前瞻性多中心试验中，470例Bishop评分不佳（3 - 4分）的患者被随机分组，分别接受阴道用前列腺素凝胶（2毫克）或宫颈内凝胶（0.5毫克）。
对于Bishop评分不佳的患者，经阴道给药途径可使宫颈成熟度更好，引产至分娩间隔更短，且24小时内累积分娩率更高（P = 0.01）。
对于Bishop评分为3 - 4分的宫颈条件不佳患者，经阴道滴注前列腺素E₂凝胶引产有效。
