Tucker R P, Martin D, Kos R, Chiquet-Ehrismann R
Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA 95616, USA.
Mech Dev. 2000 Nov;98(1-2):187-91. doi: 10.1016/s0925-4773(00)00444-5.
The teneurins are a family of four transmembrane proteins expressed in the developing vertebrate nervous system, though the Drosophila teneurin ten-m is also a pair-rule gene. Whole-mount in situ hybridization was used to localize teneurin-4 transcripts in the chicken embryo. The earliest signal is detected at stage 19 in the somites and limb buds. By stage 20 teneurin-4 transcripts are detected in temporal periocular mesenchyme, branchial arches, diencephalon and somites. Teneurin-4 expression in the limbs changes dramatically during development. Between stages 19 and 21 teneurin-4 expression is concentrated proximally in the zone of polarizing activity. Between stages 24 and 26 teneurin-4 is expressed in the mesenchyme of the anterodistal part of the limb. As in Drosophila, vertebrate teneurins are expressed not only in the nervous system, but also in non-neuronal tissues during pattern formation.
Ten-m蛋白是由四个跨膜蛋白组成的蛋白家族，在脊椎动物神经系统发育过程中表达，不过果蝇的Ten-m蛋白也是一个成对规则基因。采用全胚胎原位杂交技术在鸡胚中定位Ten-m4转录本。最早在第19期的体节和肢芽中检测到信号。到第20期时，在颞部眼周间充质、鳃弓、间脑和体节中检测到Ten-m4转录本。Ten-m4在肢体中的表达在发育过程中发生显著变化。在第19期到第21期之间，Ten-m4表达集中在近端的极化活性区。在第24期到第26期之间，Ten-m4在肢体前远端部分的间充质中表达。与果蝇一样，脊椎动物的Ten-m蛋白不仅在神经系统中表达，而且在模式形成过程中的非神经组织中也有表达。
