肠道黏膜表面的细菌相互作用：对疫苗研发的启示
Bacterial interplay at intestinal mucosal surfaces: implications for vaccine development.
作者信息
Autenrieth I B, Schmidt M A
机构信息
Institut für Medizinische Mikrobiologie, Eberhard-Karls Universität Tübingen, 72076, Tübingen, Germany.
出版信息
Trends Microbiol. 2000 Oct;8(10):457-64. doi: 10.1016/s0966-842x(00)01828-x.
The discovery of 'molecular syringes' in several important gastrointestinal pathogens including Escherichia coli, Salmonella, Shigella and Yersinia, together with a better understanding of M cells and the mucosal immune system, has advanced our appreciation of multistage microorganism-host cell interactions. Recent studies suggest that these molecular strategies could be adapted for the development of modular mucosal vaccines.
在包括大肠杆菌、沙门氏菌、志贺氏菌和耶尔森氏菌在内的几种重要胃肠道病原体中发现了“分子注射器”，同时对M细胞和黏膜免疫系统有了更深入的了解，这使我们对微生物与宿主细胞的多阶段相互作用有了更深刻的认识。最近的研究表明，这些分子策略可用于开发模块化黏膜疫苗。
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