Nunez Gabriel
Department of Pathology and Comprehensive Cancer Center, University of Michigan, Michigan, USA.
Keio J Med. 2017;66(1):14. doi: 10.2302/kjm.66-001-ABST.
The mechanisms that allow enteric pathogens to colonize the intestine and host immunity as well as the indigenous microbiota to inhibit pathogen colonization remain poorly understood. Our laboratory is using Citrobacter rodentium, a mouse pathogen that models human infections by enteropathogenic E. coli, to understand the mechanisms that regulate the colonization and clearance of the pathogen in the gut. These studies have revealed how the pathogen colonizes and replicates successfully early during infection and how host immunity and the indigenous microbiota cooperate to eradicate the pathogen in the later stage of the infection. The impairment of the immune system to control the barrier function of the intestine leads to pathogen invasion and the induction of a second layer of host protective immunity to limit the systemic spread of the pathogen.(Presented at the 1931st Meeting, January 17, 2017).
肠道病原体在肠道内定殖的机制、宿主免疫力以及肠道内微生物群抑制病原体定殖的机制仍未被充分了解。我们的实验室正在使用鼠柠檬酸杆菌，一种模拟人类肠道致病性大肠杆菌感染的小鼠病原体，来了解调节肠道内病原体定殖和清除的机制。这些研究揭示了病原体在感染早期如何成功定殖和复制，以及宿主免疫力和肠道内微生物群如何在感染后期协同作用以根除病原体。免疫系统控制肠道屏障功能的受损会导致病原体入侵，并诱导宿主产生第二层保护性免疫，以限制病原体的全身扩散。（于2017年1月17日在第1931次会议上发表）
