Bachmeyer C, Guillemette J, Blum L, Turc Y, Dhôte R, Fermand J P, Aractingi S
Département de Médecine Interne, Centre Hospitalier Laënnec, Boulevard Laënnec, BP 72, F-60109 Creil Cedex, France.
J Am Acad Dermatol. 2000 Nov;43(5 Pt 2):972-4. doi: 10.1067/mjd.2000.109254.
The association of mast cell diseases and some hematologic malignancies, usually myeloproliferative disorders, myelodysplastic syndromes, and acute leukemia is well recognized. We report the case of a patient with telangiectasia macularis eruptiva perstans, a rare form of cutaneous mastocytosis, and multiple myeloma, an association that has been described only twice in the literature. Parallel improvement of both conditions was observed under chemotherapy regimens for multiple myeloma. Pathogenesis remains unclear, although the abnormalities in the c-kit pathway may play a role in the proliferation of cells from both lineages.
肥大细胞疾病与一些血液系统恶性肿瘤的关联已得到充分认识，这些恶性肿瘤通常是骨髓增殖性疾病、骨髓增生异常综合征和急性白血病。我们报告了一例持久性斑疹性毛细血管扩张症（一种罕见的皮肤肥大细胞增多症）患者合并多发性骨髓瘤的病例，这种关联在文献中仅被描述过两次。在针对多发性骨髓瘤的化疗方案治疗下，观察到两种疾病均有好转。尽管c-kit信号通路异常可能在这两种谱系细胞的增殖中起作用，但发病机制仍不清楚。
