Barber R, Gholkar A, Scheltens P, Ballard C, McKeith I G, O'Brien J T
Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK.
Int J Geriatr Psychiatry. 2000 Oct;15(10):911-6. doi: 10.1002/1099-1166(200010)15:10<911::aid-gps217>3.0.co;2-t.
The aim of the study was to examine the relationship between white matter changes on magnetic resonance imaging (MRI), brain atrophy and ventricular dilation in late-life dementias. T(1)-weighted, T(2)-weighted, and proton density MRI scans were acquired in subjects with Alzheimer's disease (AD, N=25) and dementia with Lewy bodies (DLB, N=27). Total brain and ventricular volumes were measured and white matter lesions rated using a semi-quantitative scale. Periventricular hyperintensities (PVH) were found to independently correlate with advancing age and increasing ventricular dilatation in all subjects. In contrast, deep white matter hyperintensities (DWMH) did not correlate with measures of brain atrophy, ventricular dilatation or age, but were associated with a history of hypertension. These findings support the hypothesis that PVH and DWMH are pathologically diverse and that white matter change in AD and DLB may be determined by similar processes. In particular, PVH appear to be linked to atrophic processes involving ventricular enlargement and DWMH to ischaemic risk factors.
该研究的目的是探讨磁共振成像（MRI）上的白质变化、脑萎缩和老年期痴呆中的脑室扩张之间的关系。对患有阿尔茨海默病（AD，N = 25）和路易体痴呆（DLB，N = 27）的受试者进行了T(1)加权、T(2)加权和质子密度MRI扫描。测量了全脑和脑室体积，并使用半定量量表对白质病变进行评分。在所有受试者中，发现脑室周围高信号（PVH）与年龄增长和脑室扩张增加独立相关。相比之下，深部白质高信号（DWMH）与脑萎缩、脑室扩张或年龄的测量值无关，但与高血压病史有关。这些发现支持了以下假设：PVH和DWMH在病理上是不同的，并且AD和DLB中的白质变化可能由相似的过程决定。特别是，PVH似乎与涉及脑室扩大的萎缩过程有关，而DWMH与缺血性危险因素有关。
