Malich A, Fritsch T, Anderson R, Boehm T, Freesmeyer M G, Fleck M, Kaiser W A
Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller University Jena, Germany.
Eur Radiol. 2000;10(10):1555-61. doi: 10.1007/s003300000553.
It has long been established that cancer cells exhibit altered local dielectric properties compared with normal cells. Consequently, different electrical conductivity and capacitance are measurable in malignant vs normal tissues. In this study we evaluated the reliability of electrical impedance scanning (EIS), a new technology, for the classification of suspicious lesions: differentiating benign from malignant, and as a primary means of detection of breast cancer. Fifty-two women with 58 sonographically and/or mammographically suspicious findings were examined using electrical impedance scanning. Two different examination modes of TransScan TS2000 (Siemens, Erlangen, Germany), the standard-resolution mode for a routine overview examination, and the targeted high-resolution mode for a local examination of the suspicious lesion were used. All patients were additionally imaged by MR mammography (MRM) and underwent core-biopsy and/or surgical treatment after the EIS examination. With respect to the histopathological findings (29 malignant and 29 benign lesions) 27 of 29 (93.1%) malignant lesions were correctly identified using the high-resolution mode of EIS, whereas 19 of 29 (65.5%) benign lesions were correctly identified as benign (10 of 29 benign lesions showed as false-positive findings). Negative and positive predictive values of 90.5 and 73.0% were observed, respectively. Using the standard-resolution mode 22 of 29 malignancies were correctly detected (sensitivity 75.9%), whereas 22 of 29 were correctly identified as benign (specificity 72.4%). Electrical impedance scanning appears to be a promising new technology providing a relatively high sensitivity for the verification of suspicious mammographic and/or sonographic lesions especially using the high-resolution mode for local examinations. Artifacts, such as signals from superficial skin lesions, poor contact, and air bubbles, are currently a limitation.
长期以来，人们已经确定癌细胞与正常细胞相比表现出改变的局部介电特性。因此，在恶性组织与正常组织中可测量到不同的电导率和电容。在本研究中，我们评估了一种新技术——电阻抗扫描（EIS）用于可疑病变分类的可靠性：区分良性与恶性，并作为乳腺癌的主要检测手段。对52名有58个超声和/或乳腺X线摄影可疑发现的女性进行了电阻抗扫描检查。使用了TransScan TS2000（西门子，德国埃尔朗根）的两种不同检查模式，即用于常规概述检查的标准分辨率模式和用于可疑病变局部检查的靶向高分辨率模式。所有患者在EIS检查后还接受了乳腺磁共振成像（MRM）检查，并进行了粗针活检和/或手术治疗。根据组织病理学结果（29个恶性病变和29个良性病变），使用EIS的高分辨率模式正确识别了29个恶性病变中的27个（93.1%），而29个良性病变中的19个（65.5%）被正确识别为良性（29个良性病变中有10个显示为假阳性结果）。分别观察到阴性和阳性预测值为90.5%和73.0%。使用标准分辨率模式，29个恶性肿瘤中有22个被正确检测到（敏感性75.9%），而29个中有22个被正确识别为良性（特异性72.4%）。电阻抗扫描似乎是一种有前景的新技术，特别是使用高分辨率模式进行局部检查时，对乳腺X线摄影和/或超声可疑病变的验证具有相对较高的敏感性。目前，诸如来自浅表皮肤病变的信号、接触不良和气泡等伪像是一个限制因素。
