Racek J, Holecek V, Trefil L
Ustav klinické biochemie a laboratorní diagnostiky LF UK a FN, Plzen.
Vnitr Lek. 1999 Jun;45(6):367-72.
The level od malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARS) respectively, in blood is changing very quickly and therefore isoprostanes scam to be better markers of atherogenesis. Oxidized LDL belong to the most important reasons of the origin of foam cells and therefore of atherogenesis. That is why the inhibition of the oxidation of LDL particles should belong to the standard therapy of cardiovascular diseases. The value of antibodies against oxidized LDL is difficult to interpret, because they are multifactor dependent, especially under genetic control. Antibodies against LDL modified by malondialdehyde (MDA-LDL) are increased in smokers and individuals with a rapid atherosclerotic progression. HDL-cholesterol protects LDL through the oxidized lipid exchange. Oxidized HDL formed during this process has then an increased clearance from circulation.
血液中丙二醛（MDA）和硫代巴比妥酸反应性物质（TBARS）的水平变化非常迅速，因此异前列腺素似乎是动脉粥样硬化形成的更好标志物。氧化型低密度脂蛋白（ox-LDL）是泡沫细胞形成以及动脉粥样硬化发生的最重要原因之一。这就是为什么抑制低密度脂蛋白颗粒的氧化应成为心血管疾病的标准治疗方法。抗氧化型低密度脂蛋白抗体的值难以解释，因为它们受多种因素影响，尤其是受基因控制。吸烟者和动脉粥样硬化进展迅速的个体中，抗丙二醛修饰的低密度脂蛋白（MDA-LDL）抗体水平会升高。高密度脂蛋白胆固醇通过氧化脂质交换来保护低密度脂蛋白。在此过程中形成的氧化型高密度脂蛋白随后从循环中的清除率会增加。
