Viigimaa Margus, Abina Jelena, Zemtsovskaya Galina, Tikhaze Alla, Konovalova Galina, Kumskova Elena, Lankin Vadim
Tallinn University of Technology, Institute of Biomedical of Engineering, Tallinn, Estonia.
Blood Press. 2010 Jun;19(3):164-8. doi: 10.3109/08037051.2010.484158.
Cardiovascular diseases are accompanied by the presence of active oxygen species and organic free radical generation. The aim of this study was to examine the possibility of using malondialdehyde (MDA)-modified low-density lipoprotein (LDL) analyses as a diagnostic and prognostic biomarker.
A cross-sectional epidemiological study of a random sample of the male population of Tallinn aged 20-64 was carried out in 2007-2008. A total of 413 subjects were included in the study. The screening procedure included standard epidemiological methods. Oxidative stress was assessed by measuring the kinetics of glutathione oxidation and the level of oxidized of MDA-modified LDL.
A strong positive correlation between levels of MDA-modified LDL- and total cholesterol was indicated, as well as LDL-cholesterol in blood of patients with postinfarct cardiosclerosis (r=0.82 and r=0.83, respectively, p<0.05). Hypercholesterolemia and hyperglyceridemia were accompanied by significant increase in oxidized LDL plasma level.
MDA-modified LDL estimation has a diagnostic accuracy and may be used as an independent biochemical marker for atherosclerosis.
心血管疾病伴随着活性氧物质的存在和有机自由基的产生。本研究的目的是检验使用丙二醛（MDA）修饰的低密度脂蛋白（LDL）分析作为诊断和预后生物标志物的可能性。
2007年至2008年对塔林20 - 64岁男性人群的随机样本进行了横断面流行病学研究。共有413名受试者纳入研究。筛查程序包括标准流行病学方法。通过测量谷胱甘肽氧化动力学和MDA修饰的LDL氧化水平评估氧化应激。
MDA修饰的LDL水平与总胆固醇以及心肌梗死后心脏硬化患者血液中的LDL胆固醇之间呈强正相关（分别为r = 0.82和r = 0.83，p < 0.05）。高胆固醇血症和高甘油三酯血症伴随着氧化LDL血浆水平的显著升高。
MDA修饰的LDL评估具有诊断准确性，可作为动脉粥样硬化的独立生化标志物。
