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双向连接消毒剂预防腹膜炎效果的体外研究

In vitro study of the efficacy of a two-way connection with disinfectant in the prevention of peritonitis.

作者信息

Buoncristiani U, Bianchi P, Nasimi M, Parlani F, Covarelli C, Buoncristiani E, Bastianini L, Bistoni F

机构信息

Nephrology and Dialysis Department, Silvestrini Hospital, Perugia, Italy.

出版信息

Adv Perit Dial. 2000;16:208-12.

PMID:11045295
Abstract

A new connection system for continuous ambulatory peritoneal dialysis (CAPD) has been established, and its efficacy in preventing microbial contamination of the peritoneal cavity has been tested in vitro. The system consists of a Y-shaped channel formed in the bottom of a Plexiglas cup. The Luer-lock shaped ends of the Y-shaped channel are designed to host the connectors from the drainage bag, the catheter transfer set, and the bag of fresh dialysate. Because the connectors from the catheter transfer set and the fresh bag are located at the inner surface of the cup bed, and because the cup is filled with disinfectant during the entire exchange procedure, all at-risk steps are continuously protected by disinfectant (that is, removal of the caps from the connectors, connection and disconnection, replacement of the caps). Still, because the patient could inadvertently extract and contaminate one of the two connectors (although such a possibility is unlikely), the disinfecting efficacy of the system was tested in vitro. Despite contamination with various micro-organisms at the highest possible concentrations, all tests showed negative bacterial growth, thus confirming the absolute efficacy of the system in preventing exogenous transluminal peritonitis.

摘要

一种用于持续性非卧床腹膜透析(CAPD)的新型连接系统已建立,并在体外测试了其预防腹膜腔微生物污染的效果。该系统由有机玻璃杯底部形成的Y形通道组成。Y形通道的鲁尔锁形末端设计用于容纳引流袋、导管转接装置和新鲜透析液袋的连接器。由于导管转接装置和新鲜袋的连接器位于杯床内表面,且在整个交换过程中杯内充满消毒剂,所有有风险的步骤(即从连接器上取下帽、连接和断开连接、更换帽)都持续受到消毒剂的保护。然而,由于患者可能无意中拔出并污染两个连接器之一(尽管这种可能性不大),因此在体外测试了该系统的消毒效果。尽管以尽可能高的浓度接种了各种微生物,所有测试均显示细菌生长呈阴性,从而证实了该系统在预防外源性经腔性腹膜炎方面的绝对有效性。

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1
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Adv Perit Dial. 2000;16:208-12.
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