Rigberg S V, Brodsky I
J Med. 1975;6(3-4):271-90.
Androgenic hormones are utilized in clinical practice as a bone marrow stimulant as well as replacement therapy in certain endocrinologic disorders. In the oncologic realm breast cancer has shown some responsiveness to pharmacologic doses of androgens. However, recent work reveals that androgens are capable of stimulating the fibrinolytic mechanism and more importantly enhance the immune response. These latter properties represent a significant new role for the androgens and anabolic agents. Hence, adjunctive utilization of androgens with cancer chemotherapeutic agents may result in an effective synergistic combination in the therapy of malignant disease.
雄激素类激素在临床实践中被用作骨髓刺激剂以及某些内分泌疾病的替代疗法。在肿瘤学领域，乳腺癌已显示出对药理剂量雄激素有一定反应。然而，最近的研究表明，雄激素能够刺激纤维蛋白溶解机制，更重要的是能增强免疫反应。雄激素和合成代谢剂的这些特性代表了它们的一个重要新作用。因此，将雄激素与癌症化疗药物联合使用可能会在恶性疾病治疗中产生有效的协同组合。
