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我们是否正在了解大脑识别和控制时实际发生的情况?

Are we learning what actually goes on when the brain recognizes and controls?

作者信息

Bullock T H

出版信息

J Exp Zool. 1975 Oct;194(1):13-33. doi: 10.1002/jez.1401940103.

Abstract

Drawing upon recent advances in neuroscience for examples, the thesis is defended that, in contrast to a Kuhnian view of proress by overturning whole sciences, progress amounting to revolution in our understanding of nervous systems is happening by the accumulation of many discrete discoveries, and that this process may be expected to continue for a long time. Twelve propositions are put forward illustrative of ideas developed during and influenced by C. L. Prosser's career, all in the segment of neuroscience concerned with subsystem organization. They range from the generally accepted to the frankly polemical and the merely heuristic. (1) Ongoing background activity has different forms. (2) Codes, both spike and graded, are several. (3) Integrative variables in neuron function are several. (4) Identifiable cells may be widespread. (5) Neuronal circuits for behavior are known. (6) Redundancy is usually overlap. (7) Reliability can be high. (8) Recognition neurons may be common and complex. (9) Command neurons may be common and complex. (10) Pattern is often central in origin. (11) Hierarchies and switches may be common. (12) Subsystem function is an intellectual challenge. Each of these is briefly elaborated and its logical relation to the others suggested. The role of discrete discovery is thus illustrated--in the generation of new conceptual frameworks that gradually become interrelated and cumulatively change profoundly our picture of what's going on in the brain.

摘要

以神经科学的最新进展为例,本文捍卫了这样一种观点:与库恩所认为的通过推翻整个科学来实现进步的观点不同,我们对神经系统理解的进步是通过许多离散发现的积累而发生的,这种进步相当于一场革命,而且这个过程预计会持续很长时间。本文提出了十二个命题,用以说明在C. L. 普罗瑟的职业生涯中形成并受其影响的观点,所有这些命题都属于神经科学中与子系统组织相关的部分。这些命题的范围从普遍被接受的到坦率的论战性的,再到仅仅具有启发性的。(1)正在进行的背景活动有不同形式。(2)编码,包括脉冲编码和分级编码,有多种。(3)神经元功能中的整合变量有多种。(4)可识别的细胞可能广泛存在。(5)已知用于行为的神经元回路。(6)冗余通常是重叠的。(7)可靠性可以很高。(8)识别神经元可能常见且复杂。(9)指令神经元可能常见且复杂。(10)模式通常起源于中枢。(11)层级和开关可能很常见。(12)子系统功能是一个智力挑战。对每一个命题都进行了简要阐述,并指出了它们之间的逻辑关系。由此说明了离散发现的作用——在生成新的概念框架方面,这些框架逐渐相互关联,并深刻地累积改变我们对大脑中正在发生的事情的认识。

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