Dubovsky E V, Logic J R, Diethelm A G, Balch C M, Tauxe W N
J Nucl Med. 1975 Dec;16(12):1115-20.
By means of a comprehensive renal function test based on the analysis of orthoidohippurate kinetics carried out 223 times in 86 renal transplatn patients, we have been able to separate clearly five clinical entities: normally functioning transplanted kidneys, acute tubular necrosis, cell-mediated rejection, humoral (chromin) rejection, and postrenal obstruction. Accurate prediction of the fate of the rejecting kidney can be made while still subclinical as much as a week before manifestations by other techniques are evident. Data on 22 donors studied 44 times are also presented. The comprehensive test consists of measurements of effective renal plasma flow (ERPF), sequential scintigraphy, calculations of excretory index (EI) (percent dose actually found in bladder and voided urine as a fraction of the percent dose expected at a given time after injection at the patient's specific ERPF), and residual urine volume. Formulas and regression equations for the calculation of ERPF, EI, residual urine, etc., are presented.
通过对86例肾移植患者进行223次基于邻碘马尿酸盐动力学分析的全面肾功能测试，我们已能够清晰地分辨出五种临床情况：移植肾功能正常、急性肾小管坏死、细胞介导性排斥反应、体液（显色）排斥反应以及肾后梗阻。在其他技术出现明显表现的一周前，当排斥反应仍处于亚临床阶段时，就能对排斥肾的转归做出准确预测。文中还给出了对22名供体进行44次研究的数据。全面测试包括有效肾血浆流量（ERPF）测量、连续闪烁扫描、排泄指数（EI）计算（在患者特定ERPF下注射后给定时间，膀胱和排出尿液中实际发现的剂量百分比占预期剂量百分比的比例）以及残余尿量。文中给出了计算ERPF、EI、残余尿量等的公式和回归方程。
