Fill H, Spielberger M, Leidlmair K, Klima G
Eur J Nucl Med. 1985;11(5):171-8. doi: 10.1007/BF00251369.
A total of 485 nephrographies (NGs) performed on 95 patients in 1982 were analyzed statistically. The different modes of orthoiodine-hippuran (OIH) handling by the transplanted kidneys are summarized by six different basic curve patterns. The formation of these patterns is an effect of the prolongation of the time to the curve maximum, the time to 75% of the maximum, and the time until the intersection of the bladder and kidney curves. Also, intraparenchymal retention of activity leads to changes in the OIH curves. The basic curve patterns were correlated with the increase of serum creatinine levels, and thus, OIH-NG has to be interpreted as a differentiated marker of renal function. Renal-transplant rejection does not produce a specific pattern of OIH curve, as seen from comparison of the curve-type distribution in rejection and non rejection periods (chi 2 = 0.0866). The diagnostic values of the OIH is limited to purely functional statements, allowing only an indirect diagnosis of renal-transplant rejections without permitting the differential diagnosis of other causes of renal disturbance. OIH-NG is useful for monitoring renal function because it resolves different function levels very sensitively even at identical creatinine values. Furthermore, it makes it possible to estimate the prognosis of renal functional improvement when creatinine levels are elevated.
对1982年95例患者进行的485次肾造影（NG）进行了统计学分析。移植肾对邻碘马尿酸（OIH）的不同处理方式可归纳为六种不同的基本曲线模式。这些模式的形成是曲线达到最大值的时间、达到最大值75%的时间以及膀胱曲线和肾脏曲线相交时间延长的结果。此外，实质内活性滞留会导致OIH曲线发生变化。基本曲线模式与血清肌酐水平的升高相关，因此，OIH-NG必须被解释为肾功能的一个有区别的标志物。从排斥期和非排斥期曲线类型分布的比较（χ2 = 0.0866）可以看出，肾移植排斥反应不会产生特定的OIH曲线模式。OIH的诊断价值仅限于纯粹的功能陈述，仅能间接诊断肾移植排斥反应，而无法对其他肾脏疾病原因进行鉴别诊断。OIH-NG对于监测肾功能很有用，因为即使在肌酐值相同的情况下，它也能非常敏感地分辨出不同的功能水平。此外，当肌酐水平升高时，它还能估计肾功能改善的预后。
