抗精神病药物的受体药理学。
Receptor pharmacology of neuroleptics.
作者信息
Pearson R M
机构信息
St Bartholomew's and the Royal London Hospital School of Medicine and Dentistry.
出版信息
Hosp Med. 2000 Sep;61(9):647-9. doi: 10.12968/hosp.2000.61.9.1423.
PMID:11048607
Abstract
The term 'neuroleptic' originated from animal experiments--these drugs caused profound sedation and abnormal posturing as if the animal had been 'seized' (Greek 'lepsis', meaning seizure). All early neuroleptic drugs had antipsychotic actions and vice versa. Now there are drugs which are potent antipsychotics without the classic neuroleptic actions known as atypical neuroleptics.
摘要
“神经阻滞剂”一词源于动物实验——这些药物会引起深度镇静和异常姿势，就好像动物被“抓住”了一样（希腊语“lepsis”，意为癫痫发作）。所有早期的神经阻滞剂药物都有抗精神病作用，反之亦然。现在有一些药物是强效抗精神病药物，但没有典型的神经阻滞剂作用，被称为非典型神经阻滞剂。
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