Richelson E
Department of Psychiatry, Mayo Clinic and Foundation, Jacksonville, Fla 32224, USA.
J Clin Psychiatry. 1999;60 Suppl 10:5-14.
This article reviews the receptor pharmacology of neuroleptics, with a focus on newer drugs (e.g., risperidone, olanzapine, sertindole, quetiapine, and ziprasidone) in contrast to older compounds. All these newer compounds are considered to be atypical neuroleptics based upon certain criteria, which are reviewed. Several hypotheses about the molecular mechanisms that explain atypicality are considered. Finally, the in vitro receptor binding data presented for these compounds are related to the therapeutic and adverse effects of these drugs.
本文综述了抗精神病药物的受体药理学，重点关注与旧有化合物相比的新型药物（如利培酮、奥氮平、舍吲哚、喹硫平和齐拉西酮）。根据某些标准，所有这些新型化合物都被认为是非典型抗精神病药物，本文对这些标准进行了综述。还考虑了几种关于解释非典型性的分子机制的假说。最后，给出了这些化合物的体外受体结合数据，并将其与这些药物的治疗作用和不良反应联系起来。
