De Wever I, Dal Cin P, Fletcher C D, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Sciot R, Tallini G, Van Den Berghe H, Vanni R, Willén H
Department of Surgical Oncology, University of Leuven, Belgium.
Mod Pathol. 2000 Oct;13(10):1080-5. doi: 10.1038/modpathol.3880200.
Whether fibromatoses are neoplastic or reactive lesions has long been controversial and the relationship, if any, between the superficial and deep forms (desmoid tumors) are poorly understood. Clinical, pathologic, and cytogenetic data of 78 cases of fibromatosis were analyzed and correlated with each other. The results demonstrate that clonal chromosome aberrations are a common feature of this entity, being present in 46% of desmoid tumors, although less frequent in the superficial types (10%). In the deep-seated extra-abdominal fibromatoses, trisomies 8 and 20 and loss of 5q material were the only recurrent features. No correlation between +8 and local recurrence was found. Our findings provide additional evidence for the neoplastic nature of fibromatoses.
纤维瘤病是肿瘤性病变还是反应性病变长期以来一直存在争议，对于浅表型和深部型（硬纤维瘤）之间的关系（如果存在的话）也知之甚少。对78例纤维瘤病的临床、病理和细胞遗传学数据进行了分析并相互关联。结果表明，克隆性染色体畸变是该实体的一个常见特征，在46%的硬纤维瘤中存在，尽管在浅表型中频率较低（10%）。在深部腹外纤维瘤病中，8号和20号染色体三体以及5q物质缺失是唯一反复出现的特征。未发现+8与局部复发之间存在相关性。我们的研究结果为纤维瘤病的肿瘤性质提供了额外的证据。
