Bergmann F, Gunawan B, Hermanns B, Höer J, Schumpelick V, Füzesi L
Institute of Pathology, Rheinisch-Westfälische Technische Hochschule Aachen.
Verh Dtsch Ges Pathol. 1998;82:275-8.
We present cytogenetic findings in five gastrointestinal stromal tumors (GISTs). Three of these five cases had abnormal karyotypes with clonal chromosomal aberrations. The most common karyotypic pattern was a combined loss of chromosomes 14 and 22 in a total of three cases. Among these cases, additional recurrent chromosomal abnormalities were loss of 1p and/or 9, detected in two cases each. Another karyotypic feature consisted of polyploidisation, leading to hypotetraploid chromosome numbers in one case. These cytogenetic results provide evidence for a characteristic karyotypic pattern consisting of -14 and -22 in a subset of GISTs.
我们展示了5例胃肠道间质瘤（GIST）的细胞遗传学研究结果。这5例中的3例具有异常核型，伴有克隆性染色体畸变。最常见的核型模式是14号和22号染色体同时缺失，共有3例。在这些病例中，另外两个常见的染色体异常是1p和/或9号染色体缺失，各有2例。另一个核型特征是多倍体化，导致1例出现亚四倍体染色体数目。这些细胞遗传学结果为一部分GIST中存在由-14和-22组成的特征性核型模式提供了证据。
