van Brunt J, Edlin G
J Mol Evol. 1975 Sep 8;5(4):279-90. doi: 10.1007/BF01732215.
The lactose fermenting genes in E. coli have been transposed to various chromosomal locations. The bacterial strains were mutagenized with different chemical mutagens and the frequency of Lac negative mutant colonies was measured as a function of lactose gene location in the chromosome. There appears to be a highly mutable location between 58-60 minutes on the E. coli map. This region does not appear to be correlated with the origin of DNA replication or with the terminus. The possible significance of this mutable region in the evolution of new bacterial genes is discussed.
大肠杆菌中的乳糖发酵基因已被转移至染色体的不同位置。用不同的化学诱变剂对细菌菌株进行诱变，并测定乳糖阴性突变菌落的频率，作为乳糖基因在染色体上位置的函数。在大肠杆菌图谱上，58 - 60分钟之间似乎存在一个高度可变的位置。该区域似乎与DNA复制起点或终点无关。本文讨论了这个可变区域在新细菌基因进化中的可能意义。
