Urso C
Dermatopathology Section, SM Annunziata Hospital, Florence, Italy.
Am J Dermatopathol. 2000 Oct;22(5):391-6. doi: 10.1097/00000372-200010000-00002.
The atypical histologic features considered to be specific to dysplastic (atypical) nevi have been reported to occur in nevi that are common nevi by all other clinical and histologic features. The distribution and mutual relations among such features in nevi need to be further studied. Six histologic features (dimension > 5 mm, lentiginous proliferation, disordered nested pattern, melanocytic dyskaryosis, dermal lymphocytic infiltrate, suprabasal melanocytes) were analyzed in 253 melanocytic nevi with different clinical appearances. Atypical histologic features, found in 72% of nevi, occurred singly or formed numerous and highly variable combinations. Nevi formed a complex histologic spectrum comprising lesions showing a progressively increasing incidence of atypical features rather than two classes (common and dysplastic nevi). To divide the investigated lesions in objectively defined groups, we used a scoring system. In each nevus, a numeric value of 1 was assigned when each of the studied parameters was present and a value of 0 was assigned when each of these parameters was absent; on the basis of the final scores, nevi were divided in six different classes (classes 0-5). Diagnostic categories such as dysplastic nevi and common nevi seem to be inappropriate, as they do not reflect the real histologic complexity of such lesions.
据报道，被认为是发育异常（非典型）痣所特有的非典型组织学特征，也会出现在所有其他临床和组织学特征均为普通痣的痣中。痣中这些特征的分布及相互关系仍需进一步研究。对253例具有不同临床表现的黑素细胞痣分析了六种组织学特征（直径>5mm、雀斑样增生、巢状结构紊乱、黑素细胞发育异常、真皮淋巴细胞浸润、基底层上黑素细胞）。在72%的痣中发现了非典型组织学特征，这些特征单独出现或形成大量高度可变的组合。痣形成了一个复杂的组织学谱，包括非典型特征发生率逐渐增加的病变，而不是分为两类（普通痣和发育异常痣）。为了将研究的病变客观地分为不同组，我们使用了一个评分系统。在每个痣中，当每个研究参数出现时赋值为1，当这些参数均不存在时赋值为0；根据最终得分，痣被分为六个不同类别（0-5类）。诸如发育异常痣和普通痣等诊断类别似乎并不合适，因为它们没有反映出此类病变真正的组织学复杂性。
