Urso C, Bondi R
Institute of Anatomic Pathology, University of Firenze, Italy.
Pathol Res Pract. 1994 Jun;190(6):609-14. doi: 10.1016/s0344-0338(11)80399-7.
The histological intraepidermal characteristics considered to be specific to dysplastic nevi (radial extension, lentiginous and disordered nest proliferations, cytological atypia or dyskaryosis) were investigated in a series of 114 acquired nevi showing various clinical appearances in an attempt to establish whether dysplastic nevi can be considered a homogeneous class of lesions, clearly distinct from common nevi. On the basis of the distribution of investigated architectural features, found singly or variously associated, the examined lesions were divided into 5 groups, showing an increasing incidence of dyskaryosis. Results suggest that acquired nevi, rather than two distinct classes (common and dysplastic nevi), form a histological spectrum of lesions, within which the border between lesions implying and not implying an increased melanoma risk cannot be objectively fixed.
对114例具有不同临床表现的后天性痣进行研究，观察被认为是发育异常痣所特有的组织学表皮内特征（放射状延伸、雀斑样和巢状增生紊乱、细胞学异型性或核异质），以确定发育异常痣是否可被视为一类明确不同于普通痣的同质病变。根据所研究的单独出现或多种特征联合出现的结构特征分布，将所检查的病变分为5组，核异质发生率逐渐增加。结果表明，后天性痣形成了一个组织学病变谱，而非两个不同的类别（普通痣和发育异常痣），在这个病变谱中，提示和不提示黑色素瘤风险增加的病变之间的界限无法客观确定。
