T3/甲状腺素结合球蛋白比值与甲状腺毒症的生化检查
The T3/TBG ratio and the biochemical investigation of thyrotoxicosis.
作者信息
Attwood E C
出版信息
Clin Biochem. 1979 Jun;12(3):88-92. doi: 10.1016/s0009-9120(79)80072-7.
The relationship between serum tri-iodothyronine (T3) and thyroxine-binding globulin (TBG) has been studied in euthyroid subjects. This relationship is similar to that previously described for thyroxine (T4) and TBG. Serum T3, TBG and T4 data are presented for euthyroid subjects of all ages and the T4:T3 and T3:TBG ratios calculated. Similar data has been derived for patients with clinically proven thyrotoxicosis and for patients in which the diagnosis was in doubt. The results suggest the T3:TBG ratio enhances the use of the T3 assay to confirm thyrotoxicosis. The fact that 25% of our patients suffering from thyrotoxicosis had apparently normal serum T4 levels reinforces the contention that a serum TBG assay must be carried out as part of a basic thyroid function screen.
对甲状腺功能正常的受试者血清三碘甲状腺原氨酸（T3）与甲状腺素结合球蛋白（TBG）之间的关系进行了研究。这种关系与先前描述的甲状腺素（T4）和TBG的关系相似。给出了各年龄段甲状腺功能正常受试者的血清T3、TBG和T4数据，并计算了T4:T3和T3:TBG比值。已得出临床确诊为甲状腺毒症患者以及诊断存疑患者的类似数据。结果表明，T3:TBG比值有助于利用T3检测来确诊甲状腺毒症。我们25%的甲状腺毒症患者血清T4水平明显正常，这一事实进一步支持了在基础甲状腺功能筛查中必须进行血清TBG检测的观点。
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