Oztürk B, Güven M, Arpaci F, Kömürcü S, Ozet A, Beyzadeoğlu M
Department of Medical Oncology, Gülhane Military Medical Academy, Ankara, Turkey.
Biol Trace Elem Res. 2000 Feb;73(2):181-7. doi: 10.1385/BTER:73:2:181.
Plasma and erythrocyte lipid peroxidation levels of 20 patients with histopathologically confirmed testis cancer and 20 healthy control individuals were studied between November 1995 and June 1997. The group with testis cancer had a mean age of 24.8+/-8.2 yr and the control group's mean age was 28.3+/-6.9 yr. Stage distribution of the testis cancer cases were 4 of stage A, 10 of stage B, and 6 of stage C. Blood samples of the patients were drawn after orchiectomy and after 12 h fasting before chemotherapy. Mean plasma and erythrocyte lipid peroxidation levels were detected to be 14.51+/-5.30 nmol malondialdehide (MDA)/mL and 9.30+/-2.06 nmol MDA/g hemoglobin (Hb), respectively, in the testis cancer group, whereas the healthy control group had mean plasma and erythrocyte lipid peroxidation levels of 10.7+/-1.82 nmol MDA/mL and 6.18+/-1.68 nmol MDA/g Hb, respectively. Plasma and erythrocyte lipid peroxidation values of the testis cancer patients were determined to be statistically significantly higher than that of the health control group (p < 0.001, p < 0.001). No significant correlation was determined between plasma, erythrocyte lipid peroxidation levels and tumor markers. In conclusion, it can be said that an increase in the lipid peroxidation may play a role in the pathogenesis of testis carcinomas in addition to the other causes.
1995年11月至1997年6月期间，对20例经组织病理学确诊为睾丸癌的患者和20名健康对照者的血浆和红细胞脂质过氧化水平进行了研究。睾丸癌组的平均年龄为24.8±8.2岁，对照组的平均年龄为28.3±6.9岁。睾丸癌病例的分期分布为：A期4例，B期10例，C期6例。患者的血样在睾丸切除术后和化疗前禁食12小时后采集。睾丸癌组的平均血浆和红细胞脂质过氧化水平分别检测为14.51±5.30 nmol丙二醛（MDA）/mL和9.30±2.06 nmol MDA/g血红蛋白（Hb），而健康对照组的平均血浆和红细胞脂质过氧化水平分别为10.7±1.82 nmol MDA/mL和6.18±1.68 nmol MDA/g Hb。睾丸癌患者的血浆和红细胞脂质过氧化值经测定在统计学上显著高于健康对照组（p < 0.001，p < 0.001）。血浆、红细胞脂质过氧化水平与肿瘤标志物之间未发现显著相关性。总之，可以说除其他原因外，脂质过氧化增加可能在睾丸癌的发病机制中起作用。
