随着年龄增长以及在冠心病患者中，红细胞脂质过氧化损伤以及血清低密度脂蛋白胆固醇、载脂蛋白B、铁蛋白和尿酸水平升高。

Lipid peroxidative damage in the erythrocytes and elevation of serum LDL-cholesterol, apolipoprotein-B, ferritin and uric acid with age and in coronary heart disease patients.

作者信息

El-Gebali H H, Tahir S A, Haider S S, El-Fakhri M M

机构信息

Department of Biochemistry, Al-Arab Medical University, Faculty of Medicine, Benghazi, Libya.

出版信息

Saudi Med J. 2000 Feb;21(2):184-9.

PMID:11533779

Abstract

OBJECTIVES

To determine the normal serum levels of LDL-cholesterol, apolipoprotein-B, ferritin, uric acid, and the extent of erythrocytes lipid peroxidation in healthy control group subjects and to compare them with coronary heart disease patients. Secondly, to study the effects of age and sex on these parameters.

METHODS

The blood samples from 150 healthy Libyan control group subjects (110 men and 40 women) were classified into 3 groups according to their age. Group I consisted of 76 subjects with an age range from 20 to 35 years. Group II consisted of 45 subjects with an age range from 36 to 50 years. Group III consisted of 29 subjects with an age range from 51 to 74 years. The blood samples from these groups were analyzed for LDL-cholesterol, apolipoprotein-B, ferritin and uric acid levels. Lipid peroxidation was compared in the erythrocytes of 56 selected healthy control group subjects (31 men and 11 women) of the aforementioned age groups.

RESULTS

These parameters have shown age-dependent elevation in their levels. Meanwhile, LDL-cholesterol and Apolipoprotein-B levels in female subjects were higher than those of males. However, lipid peroxidation in the erythrocytes has revealed a statistically significant increase with increasing age. The comparison between 93 selected, sex and age matched, healthy control group subjects with 87 selected coronary heart disease patients (55 men and 45 women) with an age range from 30 to 74 years (49.6+13.25) has demonstrated significantly higher concentration of LDL-cholesterol, Apolipoprotein-B, ferritin and uric acid in coronary heart disease patients than those of healthy control group subjects. Meanwhile, lipid peroxidation was also significantly enhanced in coronary heart disease patients compared with healthy control group subjects.

CONCLUSION

Our study has revealed that an increase in the lipid peroxidation in erythrocytes with age and during coronary heart disease, makes red cell membranes more vulnerable to free radical damage via formation of reactive oxygen species. It is thus likely that peroxidative damage may be contributing to an increase in serum LDL-cholesterol, Apolipoprotein-B, probably after its oxidative modification, increase in ferritin and hyperuricemia in coronary heart disease patients.

摘要

目的

测定健康对照组受试者血清中低密度脂蛋白胆固醇、载脂蛋白B、铁蛋白、尿酸的正常水平以及红细胞脂质过氧化程度，并与冠心病患者进行比较。其次，研究年龄和性别对这些参数的影响。

方法

从150名利比亚健康对照组受试者（110名男性和40名女性）采集血样，根据年龄分为3组。第一组由76名年龄在20至35岁之间的受试者组成。第二组由45名年龄在36至50岁之间的受试者组成。第三组由29名年龄在51至74岁之间的受试者组成。对这些组的血样进行低密度脂蛋白胆固醇、载脂蛋白B、铁蛋白和尿酸水平分析。在上述年龄组的56名选定健康对照组受试者（31名男性和11名女性）的红细胞中比较脂质过氧化情况。

结果

这些参数的水平呈现出随年龄增长而升高的趋势。同时，女性受试者的低密度脂蛋白胆固醇和载脂蛋白B水平高于男性。然而，红细胞中的脂质过氧化随着年龄的增长呈现出统计学上的显著增加。对93名选定的、年龄和性别匹配的健康对照组受试者与87名选定的年龄在30至74岁（49.6+13.25）的冠心病患者（55名男性和45名女性）进行比较，结果显示冠心病患者的低密度脂蛋白胆固醇、载脂蛋白B、铁蛋白和尿酸浓度显著高于健康对照组受试者。同时，与健康对照组受试者相比，冠心病患者的脂质过氧化也显著增强。