口服2,2-双（4-羟苯基）丙烷（双酚A）在妊娠大鼠体内的处置及胎盘向胎儿的转运。
Disposition of orally administered 2,2-Bis(4-hydroxyphenyl)propane (Bisphenol A) in pregnant rats and the placental transfer to fetuses.
作者信息
Takahashi O, Oishi S
机构信息
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Tokyo, Japan.
出版信息
Environ Health Perspect. 2000 Oct;108(10):931-5. doi: 10.1289/ehp.00108931.
Abstract
We studied the disposition of bisphenol A (BPA) in pregnant female F344/DuCrj(Fischer) rats and its placental transfer to fetuses after a single oral administration of 1 g/kg BPA dissolved in propylene glycol. BPA in maternal blood, liver, and kidney reached maximal concentrations (14.7, 171, and 36 microg/g) 20 min after the administration and gradually decreased. The levels were 2-5% of the maximum 6 hr after the administration. The maximal concentration of BPA in fetuses (9 microg/g) was also attained 20 min after the administration. BPA levels then gradually reduced in a similar manner to maternal blood. These results suggest that the absorption and distribution of BPA in maternal organs and fetuses are extremely rapid and that the placenta does not act as a barrier to BPA.
摘要
我们研究了双酚A（BPA）在怀孕的雌性F344/DuCrj（Fischer）大鼠体内的处置情况，以及在单次口服溶解于丙二醇中的1 g/kg BPA后，其通过胎盘向胎儿的转移情况。给药后20分钟，母体血液、肝脏和肾脏中的BPA达到最高浓度（分别为14.7、171和36微克/克），随后逐渐下降。给药6小时后，这些水平为最高值的2 - 5%。给药后20分钟，胎儿体内的BPA也达到最高浓度（9微克/克）。随后，BPA水平以与母体血液相似的方式逐渐降低。这些结果表明，BPA在母体器官和胎儿体内的吸收和分布极其迅速，并且胎盘对BPA不起屏障作用。
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