Cohen Annastelle, Popowitz Jeremy, Delbridge-Perry Mikayla, Rowe Cassie J, Connaughton Victoria P
Department of Biology, American University, Washington, DC, WA, United States.
Department of Chemistry, American University, Washington, DC, WA, United States.
Front Pharmacol. 2022 Feb 28;13:837687. doi: 10.3389/fphar.2022.837687. eCollection 2022.
Visual system development is a highly complex process involving coordination of environmental cues, cell pathways, and integration of functional circuits. Consequently, a change to any step, due to a mutation or chemical exposure, can lead to deleterious consequences. One class of chemicals known to have both overt and subtle effects on the visual system is endocrine disrupting compounds (EDCs). EDCs are environmental contaminants which alter hormonal signaling by either preventing compound synthesis or binding to postsynaptic receptors. Interestingly, recent work has identified neuronal and sensory systems, particularly vision, as targets for EDCs. In particular, estrogenic and thyroidogenic signaling have been identified as critical modulators of proper visual system development and function. Here, we summarize and review this work, from our lab and others, focusing on behavioral, physiological, and molecular data collected in zebrafish. We also discuss different exposure regimes used, including long-lasting effects of developmental exposure. Overall, zebrafish are a model of choice to examine the impact of EDCs and other compounds targeting estrogen and thyroid signaling and the consequences of exposure in visual system development and function.
视觉系统的发育是一个高度复杂的过程，涉及环境线索、细胞通路的协调以及功能回路的整合。因此，由于突变或化学物质暴露而导致的任何步骤的改变都可能产生有害后果。一类已知对视觉系统有明显和微妙影响的化学物质是内分泌干扰化合物（EDCs）。EDCs是环境污染物，它们通过阻止化合物合成或与突触后受体结合来改变激素信号。有趣的是，最近的研究已经确定神经元和感觉系统，特别是视觉，是EDCs的作用靶点。特别是，雌激素信号和甲状腺信号已被确定为正常视觉系统发育和功能的关键调节因子。在这里，我们总结并回顾了我们实验室和其他实验室的这项工作，重点关注在斑马鱼中收集的行为、生理和分子数据。我们还讨论了所采用的不同暴露方案，包括发育暴露的长期影响。总体而言，斑马鱼是研究EDCs和其他针对雌激素和甲状腺信号的化合物的影响以及视觉系统发育和功能中暴露后果的首选模型。
