Boesken W H
Klin Wochenschr. 1975 May 15;53(10):473-9. doi: 10.1007/BF01468633.
The urinary protein pattern following tubular damage is different from other proteinurias. The tubular proteinuria consists of micromolecular proteins of MW 10-70000. The disturbed tubular function probably leads to a diminished reabsorption of these microproteins from the tubular fluids. By determining the molecular weight of the urinary proteins by SDS-PAA-electrophoresis tubular proteinurias may be distinguished from glomerular and extrarenal forms. Tubular proteinurias are found in inflammatory, degenerative and vascular tubulopathies. The course of acute tubular diseases reveals proteinurias of different micromolecular composition depending of the improving tubular function; this supports the concept of a selective tubular reabsorption of microproteins. Tubular proteinurias are associated with normal as well as with impaired glomerular filtration, which, in part, might influence the amount of microproteins excreted.
肾小管损伤后的尿蛋白模式与其他蛋白尿不同。肾小管蛋白尿由分子量为10 - 70000的小分子蛋白质组成。肾小管功能紊乱可能导致这些微蛋白从肾小管液中的重吸收减少。通过SDS - PAA电泳测定尿蛋白的分子量，可将肾小管蛋白尿与肾小球性和肾外性蛋白尿区分开来。肾小管蛋白尿见于炎症性、退行性和血管性肾小管疾病。急性肾小管疾病的病程显示，根据肾小管功能的改善情况，蛋白尿具有不同的小分子组成；这支持了微蛋白选择性肾小管重吸收的概念。肾小管蛋白尿与正常以及受损的肾小球滤过相关，这在一定程度上可能影响微蛋白的排泄量。
