Mcclure H M, Wilk A L, Horigan E A, Pratt R M
Cleft Palate J. 1979 Jul;16(3):248-56.
Administration of cyclophosphamide to pregnant rhesus monkeys induces two syndromes of craniofacial malformations characterized by underdevelopment of the face of different pattern depending on the timing of treatment. The first is cleft lip with cleft palate and exophthalmos. The second is a craniofacial dysmorphia with marked underdevelopment of the midfacial bones, highly arched closed palate, and either meningoencephalocele or persistent anterior fontanel. Since cleft lip and palate are among the most common malformations in man, and several human syndromes involving abnormal craniofacial development have features in common with the dysmorphic monkeys, these induced anomalies may prove valuable in investigations on the pathogenesis of such malformations and as surgical models.
给怀孕的恒河猴注射环磷酰胺会诱发两种颅面畸形综合征，根据治疗时间的不同，其特征为面部发育不全，呈现不同的模式。第一种是唇腭裂和眼球突出。第二种是颅面畸形，面中部骨骼明显发育不全，硬腭高拱闭合，伴有脑膜膨出或前囟持续未闭。由于唇腭裂是人类最常见的畸形之一，而且几种涉及颅面发育异常的人类综合征与畸形猴有共同特征，这些诱发的异常情况可能在研究此类畸形的发病机制以及作为手术模型方面具有重要价值。
