Cantos R, Cole L K, Acampora D, Simeone A, Wu D K
National Institute on Deafness and Other Communication Disorders, Rockville, MD 20850, USA.
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11707-13. doi: 10.1073/pnas.97.22.11707.
The mammalian cochlea is sophisticated in its function and highly organized in its structure. Although the anatomy of this sense organ has been well documented, the molecular mechanisms underlying its development have remained elusive. Information generated from mutant and knockout mice in recent years has increased our understanding of cochlear development and physiology. This article discusses factors important for the development of the inner ear and summarizes cochlear phenotypes of mutant and knockout mice, particularly Otx and Otx2. We also present data on gross development of the mouse cochlea.
哺乳动物的耳蜗功能复杂，结构高度有序。尽管这个感觉器官的解剖结构已有详尽记录，但其发育的分子机制仍不清楚。近年来从突变体和基因敲除小鼠获得的信息增进了我们对耳蜗发育和生理学的理解。本文讨论了内耳发育的重要因素，并总结了突变体和基因敲除小鼠的耳蜗表型，特别是Otx和Otx2。我们还展示了小鼠耳蜗总体发育的数据。
