使用基因表达序列分析技术分析未知转录组
Analysing uncharted transcriptomes with SAGE.
作者信息
Velculescu V E, Vogelstein B, Kinzler K W
机构信息
Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, 1650 Orleans St., Baltimore MD 21231, USA.
出版信息
Trends Genet. 2000 Oct;16(10):423-5. doi: 10.1016/s0168-9525(00)02114-4.
Abstract
Methods of comprehensive gene expression analysis have traditionally been limited to analysing bulk tissue or millions of cells. New modifications of serial analysis of gene expression (SAGE) have now permitted the analysis of gene expression in cell subpopulations or microanatomic structures, providing access to unexplored transcriptomes of normal and disease biology.
摘要
传统上，综合基因表达分析方法仅限于分析大块组织或数百万个细胞。基因表达序列分析（SAGE）的新改进现在允许对细胞亚群或微观解剖结构中的基因表达进行分析，从而能够探究正常生物学和疾病生物学中尚未探索的转录组。
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