Rokas A, Holland PW
Trends Ecol Evol. 2000 Nov 1;15(11):454-459. doi: 10.1016/s0169-5347(00)01967-4.
DNA sequence data have offered valuable insights into the relationships between living organisms. However, most phylogenetic analyses of DNA sequences rely primarily on single nucleotide substitutions, which might not be perfect phylogenetic markers. Rare genomic changes (RGCs), such as intron indels, retroposon integrations, signature sequences, mitochondrial and chloroplast gene order changes, gene duplications and genetic code changes, provide a suite of complementary markers with enormous potential for molecular systematics. Recent exploitation of RGCs has already started to yield exciting phylogenetic information.
DNA序列数据为了解生物之间的关系提供了宝贵的见解。然而，大多数DNA序列的系统发育分析主要依赖于单核苷酸替换，而这可能并非完美的系统发育标记。罕见的基因组变化（RGCs），如内含子插入缺失、逆转座子整合、特征序列、线粒体和叶绿体基因顺序变化、基因复制以及遗传密码变化，提供了一系列具有巨大分子系统学潜力的互补标记。最近对RGCs的利用已经开始产生令人兴奋的系统发育信息。
