乳腺癌1号基因（BRCA1）：探寻其与转录的联系
BRCA1: exploring the links to transcription.
作者信息
Monteiro A N
机构信息
Dept of Cell Biology, Weill Medical College of Cornell University, New York, NY 10021, USA.
出版信息
Trends Biochem Sci. 2000 Oct;25(10):469-74. doi: 10.1016/s0968-0004(00)01632-7.
Abstract
Progress on determining the function of the breast and ovarian cancer susceptibility gene BRCA1 suggests it might be involved in two fundamental cellular processes: DNA repair and transcriptional regulation. Recent developments indicate that BRCA1 is a multifunctional protein, and disruption of its transcriptional activity could be crucial for tumor development.
摘要
确定乳腺癌和卵巢癌易感基因BRCA1功能的研究进展表明，它可能参与两个基本的细胞过程：DNA修复和转录调控。最近的研究进展表明，BRCA1是一种多功能蛋白质，其转录活性的破坏可能对肿瘤发展至关重要。
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