Jackson T R, Kearns B G, Theibert A B
Dept of Haematology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St, NW3 2PF, London, UK.
Trends Biochem Sci. 2000 Oct;25(10):489-95. doi: 10.1016/s0968-0004(00)01644-3.
Receptor-activated phosphoinositide (PI) 3-kinases produce PtdIns(3, 4,5)P(3) and its metabolite PtdIns(3,4)P(2) that function as second messengers in membrane recruitment and activation of target proteins. The cytohesin and centaurin protein families are potential targets for PtdIns(3,4,5)P(3) that also regulate and interact with Arf GTPases. Consequently, these families are poised to transduce PI 3-kinase activation into coordinated control of Arf-dependent pathways. Proposed downstream events in PI 3-kinase-regulated Arf cascades include modulation of vesicular trafficking and the actin cytoskeleton.
受体激活的磷酸肌醇（PI）3激酶产生磷脂酰肌醇-3,4,5-三磷酸（PtdIns(3, 4,5)P(3)）及其代谢产物磷脂酰肌醇-3,4-二磷酸（PtdIns(3,4)P(2)），它们作为第二信使参与膜募集和靶蛋白激活过程。细胞黏附分子蛋白家族和centaurin蛋白家族是磷脂酰肌醇-3,4,5-三磷酸（PtdIns(3,4,5)P(3)）的潜在靶点，这些靶点也可调节Arf鸟苷三磷酸酶（Arf GTPases）并与之相互作用。因此，这些家族随时准备将PI 3激酶激活转化为对Arf依赖性途径的协同控制。PI 3激酶调节的Arf级联反应中，推测的下游事件包括对囊泡运输和肌动蛋白细胞骨架的调节。
