Monroe S, Polk R
Medical College of Virginia, Richmond, Virginia 23298, USA.
Curr Opin Microbiol. 2000 Oct;3(5):496-501. doi: 10.1016/s1369-5274(00)00129-6.
The current epidemic of bacterial resistance is attributed, in part, to the overuse of antibiotics. Recent studies have documented increases in resistance with over-use of particular antibiotics and improvements in susceptibility when antibiotic use is controlled. The most effective means of improving use of antibiotics is unknown. Comprehensive management programs directed by multi-disciplinary teams, computer-assisted decision-making, and antibiotic cycling have been beneficial in controlling antibiotic use, decreasing costs without impacting patient outcomes, and possibly decreasing resistance.
当前的细菌耐药性流行，部分归因于抗生素的过度使用。近期研究记录了特定抗生素过度使用导致的耐药性增加，以及抗生素使用得到控制时敏感性的改善。改善抗生素使用的最有效方法尚不清楚。由多学科团队指导的综合管理方案、计算机辅助决策和抗生素轮换，在控制抗生素使用、降低成本且不影响患者预后以及可能降低耐药性方面已显现出成效。
