Rybak Michael J
Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA.
Pharmacotherapy. 2007 Oct;27(10 Pt 2):131S-135S. doi: 10.1592/phco.27.10part2.131S.
In response to the global antibiotic resistance crisis, antimicrobial stewardship programs have emerged throughout the United States. Effective programs integrate several strategic methods, including evaluation and feedback regarding the necessity and appropriateness of antimicrobial therapy, staff education, and formulary restrictions. Multidisciplinary teams as well as institutional support are needed to form effective subcommittees to monitor national and local surveillance reports and resistance patterns, and to update antibiograms. Computerized decision support programs have been effective and successful methods of antimicrobial stewardship and can be a powerful tool in stewardship programs. Successful programs have reduced not only institutional resistance rates, but also morbidity, mortality, and cost.
为应对全球抗生素耐药危机，美国各地纷纷涌现出抗菌药物管理项目。有效的项目整合了多种战略方法，包括对抗菌治疗的必要性和适当性进行评估与反馈、开展员工教育以及实施药品目录限制。需要多学科团队以及机构支持来组建有效的小组委员会，以监测国家和地方的监测报告及耐药模式，并更新抗菌谱。计算机化决策支持项目是抗菌药物管理的有效且成功的方法，并且可以成为管理项目中的有力工具。成功的项目不仅降低了机构的耐药率，还降低了发病率、死亡率和成本。
