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Human diadenosine triphosphate hydrolase: preliminary characterisation and comparison with the Fhit protein, a human tumour suppressor.

作者信息

Asensio A C, Rodríguez-Ferrer C R, Oaknin S, Rotllán P

机构信息

Department of Biochemistry and Molecular Biology, University of La Laguna, Tenerife, Canary Islands, Spain.

出版信息

Acta Biochim Pol. 2000;47(2):435-41.

PMID:11051208
Abstract

Human platelets diadenosine triphosphatase was characterised and compared with the Fhit protein, a human tumour suppressor with diadenosine triphosphatase activity. Both enzymes exhibit similar Km, are similarly activated by Mg2+, Ca2+ and Mn2+, and inhibited by Zn2+ and suramin. However, they are differentially inhibited by Fhit antibodies and exhibit differences in gel-filtration behaviour.

摘要

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