Gottfredsson M, Perfect J R
Department of Medicine, National University Hospital, Reykjavik, Iceland.
Semin Neurol. 2000;20(3):307-22. doi: 10.1055/s-2000-9394.
Fungi provide many benefits to humans. However, some of these fungi have the ability to become human pathogens. All the major fungal pathogens can produce meningitis. From the common cryptococcal meningitis to the rare fungal meningitis caused by a dimorphic or filamentous fungus, medical issues are discussed in this review on a fungus-specific basis. Both primary (Cryptococcus, Blastomyces, Histoplasma, Coccidioides, and other dimorphic fungi) and secondary (Aspergillus, Candida, and a series of molds) fungal pathogens can produce life-threatening central nervous system infections. These infections require immediate and precise diagnosis and carefully selected management strategies to optimize outcomes. In this review, we examine the epidemiology, pathogenesis, clinical manifestations, and treatment for fungal meningitis in all the major fungal groups.
真菌给人类带来诸多益处。然而，其中一些真菌有能力成为人类病原体。所有主要的真菌病原体都可引发脑膜炎。从常见的隐球菌性脑膜炎到由双相型或丝状真菌引起的罕见真菌性脑膜炎，本综述将基于特定真菌对医学问题进行讨论。原发性（隐球菌、芽生菌、组织胞浆菌、球孢子菌及其他双相型真菌）和继发性（曲霉菌、念珠菌及一系列霉菌）真菌病原体均可导致危及生命的中枢神经系统感染。这些感染需要立即进行精确诊断并精心选择管理策略以优化治疗效果。在本综述中，我们研究了所有主要真菌类群中真菌性脑膜炎的流行病学、发病机制、临床表现及治疗方法。
