Mastrianni J A, Roos R P
Department of Neurology, The University of Chicago Medical Center, Illinois 60637, USA.
Semin Neurol. 2000;20(3):337-52. doi: 10.1055/s-2000-9396.
The prion diseases constitute an unusual group of neurodegenerative disorders. Although they are similar in many ways to other more common diseases, such as Alzheimer disease and amyotrophic lateral sclerosis, they are set apart on the basis of their transmissible nature. In addition to the unique feature of transmissibility, the prion diseases demonstrate that the expression of diverse disease phenotypes is possible from a common etiologic factor. This review provides the reader with a basic understanding of the nature of prions and highlights the clinical and pathologic features of these fascinating diseases.
朊病毒疾病构成了一组不同寻常的神经退行性疾病。尽管它们在许多方面与其他更常见的疾病相似，如阿尔茨海默病和肌萎缩侧索硬化症，但它们因其可传播的性质而有所不同。除了独特的可传播特征外，朊病毒疾病还表明，从一个共同的病因因素可能会出现多种疾病表型。这篇综述为读者提供了对朊病毒本质的基本理解，并突出了这些迷人疾病的临床和病理特征。
