Greenlee J E, Rose J W
Neurology Service, Veterans Affairs Medical Center and Department of Neurology, University of Utah Health Science Center, Salt Lake City 84148-001, USA.
Semin Neurol. 2000;20(3):375-86. doi: 10.1055/s-2000-9429.
The past several years have seen major advances in our understanding of neurological infectious diseases, their diagnosis, and their treatment. Along with these advances, however, new information about infectious agents and new therapeutic options have also introduced both uncertainty and controversy in the approach and management of patients with diseases of the central nervous system. Here, we discuss six such areas: the long-term efficacy of HAART therapy in treatment of HIV infection; the role of viral infection in chronic fatigue syndrome; Rasmussen's encephalitis as an infectious or autoimmune disease; the spectrum of neurological diseases caused by rickettsial infection; the role of Mycoplasma pneumoniae in human central nervous system disease; and the possible association of Chlamydia pneumoniae and human herpesvirus 6 with multiple sclerosis.
在过去几年里，我们对神经感染性疾病的理解、诊断及治疗取得了重大进展。然而，伴随着这些进展，关于感染因子的新信息和新的治疗选择也给中枢神经系统疾病患者的治疗方法和管理带来了不确定性和争议。在此，我们讨论六个这样的领域：高效抗逆转录病毒治疗（HAART）对治疗HIV感染的长期疗效；病毒感染在慢性疲劳综合征中的作用；拉斯穆森脑炎是感染性疾病还是自身免疫性疾病；立克次体感染所致神经疾病的范围；肺炎支原体在人类中枢神经系统疾病中的作用；以及肺炎衣原体和人疱疹病毒6与多发性硬化症之间可能存在的关联。
