Szczuciński Adam, Losy Jacek
Zakład Neuroimmunologii Klinicznej Katedry Neurologii, Akademii Medycznej w Poznaniu.
Przegl Epidemiol. 2006;60 Suppl 1:160-5.
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) of a still unknown etiology. Genetic factors, environmental agents and an autoimmune response may play an important role in the pathogenesis of MS. In the paper the current opinion on the role of infectious agents in the pathogenesis of MS is presented. The results of epidemiological and serological studies are discussed as well as the results of viral isolation attempts and the search for virus structures in the CNS of MS patients. The most important findings in the field e.g. a potential role of Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6) and bacteria Chlamydia pneumoniae in MS are presented. Postulated mechanisms of virus-induced demyelination are also described.
多发性硬化症（MS）是一种中枢神经系统（CNS）的慢性脱髓鞘疾病，其病因尚不明确。遗传因素、环境因素和自身免疫反应可能在MS的发病机制中起重要作用。本文阐述了关于感染因子在MS发病机制中作用的当前观点。讨论了流行病学和血清学研究结果，以及病毒分离尝试的结果和在MS患者中枢神经系统中寻找病毒结构的结果。介绍了该领域最重要的发现，例如爱泼斯坦-巴尔病毒（EBV）、人类疱疹病毒6型（HHV-6）和肺炎衣原体在MS中的潜在作用。还描述了病毒诱导脱髓鞘的假定机制。
