Rulon L L, Robertson J D, Lovell M A, Deibel M A, Ehmann W D, Markesber W R
Department of Chemistry, University of Kentucky, Lexington 40506-0055, USA.
Biol Trace Elem Res. 2000 Summer;75(1-3):79-85. doi: 10.1385/bter:75:1-3:79.
Concentrations of zinc in postmortem serum and four brain regions were measured by flame atomic absorption spectrometry and instrumental neutron activation analysis, respectively, in nine Alzheimer's disease (AD) and eight control subjects. A statistically significant elevation of zinc serum was observed in AD subjects (136.4+/-66.8 microg/dL) compared with age-matched control subjects (71.1+/-35.0 microg/dL). No significant differences were observed between AD and control zinc concentrations in the amygdala, hippocampus, cerebellum, and superior and middle temporal gryi.
分别采用火焰原子吸收光谱法和仪器中子活化分析法，测定了9例阿尔茨海默病（AD）患者和8例对照者死后血清及四个脑区的锌浓度。与年龄匹配的对照者（71.1±35.0μg/dL）相比，AD患者血清锌水平有统计学意义的升高（136.4±66.8μg/dL）。杏仁核、海马体、小脑以及颞上回和颞中回的锌浓度在AD患者和对照者之间未观察到显著差异。
