使用铃木型交叉偶联反应的3-碘咪唑并[1,2-a]吡啶的反应活性
Reactivity of 3-iodoimidazo[1,2-a]pyridines using a Suzuki-type cross-coupling reaction.
作者信息
Enguehard C, Renou J L, Collot V, Hervet M, Rault S, Gueiffier A
机构信息
Laboratoire de Chimie Thérapeutique, UFR des Sciences Pharmaceutiques, Tours, France.
出版信息
J Org Chem. 2000 Oct 6;65(20):6572-5. doi: 10.1021/jo000698z.
PMID:11052104
Abstract
The influence of base and solvent in Suzuki cross-coupling reaction on various 2-substituted-3-iodoimidazo[1,2-a]pyridines was reported. The reactivity was largely influenced by nature of the substituent. Optimized yields and shortened times of reaction were obtained using strong bases in DME.
摘要
报道了Suzuki交叉偶联反应中碱和溶剂对各种2-取代-3-碘咪唑并[1,2-a]吡啶的影响。反应活性在很大程度上受取代基性质的影响。在二甲基醚（DME）中使用强碱可获得优化的产率并缩短反应时间。
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