咪唑杂环与芳基肼的无金属C-H芳基化反应。
Metal-free C-H arylation of imidazoheterocycles with aryl hydrazines.
作者信息
Jana Sourav, Samanta Sadhanendu, Bagdi Avik K, Shirinian Valerii Z, Hajra Alakananda
机构信息
Department of Chemistry, Visva-Bharati (A Central University) Santiniketan 731235 West Bengal India
Department of Chemistry, TDB College Raniganj Burdwan 713347 India.
出版信息
RSC Adv. 2018 Apr 3;8(22):12360-12367. doi: 10.1039/c8ra01474d. eCollection 2018 Mar 26.
A simple and efficient metal-free arylation of imidazo[1,2-]pyridines at the C-3 position with arylhydrazine has been achieved at room temperature under ambient air conditions. Various 2,3-disubstituted imidazopyridines and imidazothiazoles were synthesized with high yields. The present methodology demonstrates the usefulness of commercially available aryl hydrazine as an arylating agent.
在室温及环境空气条件下，实现了一种简单高效的无金属方法，使咪唑并[1,2 - ]吡啶在C - 3位与芳基肼进行芳基化反应。以高产率合成了各种2,3 - 二取代的咪唑并吡啶和咪唑并噻唑。本方法证明了市售芳基肼作为芳基化试剂的实用性。
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