Walters J R, Ruskin D N, Allers K A, Bergstrom D A
Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1406, USA.
Trends Neurosci. 2000 Oct;23(10 Suppl):S41-7. doi: 10.1016/s1471-1931(00)00024-0.
Dopamine agonist administration induces changes in firing rate and pattern in basal ganglia nuclei that provide an insight into the role of dopamine in basal ganglia function. These changes support a more complex, integrated basal ganglia network than envisioned in early models. Functionally important effects on basal ganglia output involve alterations in burstiness, synchronization and oscillatory activity,as well as rate. Multisecond oscillations in basal ganglia firing rates are markedly affected by systemic administration of dopamine-receptor agonists. This suggests that coordinated changes in neuronal activity at time scales longer than commonly investigated play a role in the cognitive and motor processes that are modulated by dopamine.
给予多巴胺激动剂会引起基底神经节核团放电频率和模式的变化，这有助于深入了解多巴胺在基底神经节功能中的作用。这些变化支持了一个比早期模型所设想的更为复杂、整合的基底神经节网络。对基底神经节输出具有重要功能的影响包括爆发性、同步性和振荡活动以及频率的改变。全身给予多巴胺受体激动剂会显著影响基底神经节放电频率的多秒振荡。这表明，在比通常研究的时间尺度更长的时间尺度上，神经元活动的协调变化在受多巴胺调节的认知和运动过程中发挥作用。
