Gerfen C R
Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892-4075, USA.
Trends Neurosci. 2000 Oct;23(10 Suppl):S64-70. doi: 10.1016/s1471-1931(00)00019-7.
Gene regulation studies demonstrate that dopamine differentially regulates the direct and indirect projection neurons of the striatum through their respective expression of the D1 and D2 dopamine receptors. Induction of immediate-early genes (IEGs) in striatal neurons is used to study dopamine-receptor-mediated neuronal plasticity. In the dopamine-depleted striatum there is a switch in receptor-mediated signal transduction mechanisms to produce a supersensitive form of D1- mediated neuronal plasticity. This switch is suggested to underlie dopamine-agonist-induced dyskinetic movements that develop during the treatment of Parkinson's disease.
基因调控研究表明，多巴胺通过纹状体直接和间接投射神经元各自表达的D1和D2多巴胺受体，对它们进行差异性调节。纹状体神经元中即刻早期基因（IEGs）的诱导被用于研究多巴胺受体介导的神经元可塑性。在多巴胺耗竭的纹状体中，受体介导的信号转导机制会发生转变，以产生一种超敏形式的D1介导的神经元可塑性。这种转变被认为是帕金森病治疗期间多巴胺激动剂诱导的运动障碍的基础。
