Yamamoto A, Okubo Y, Oshima H, Oh-i T, Koga M
Department of Dermatology, Tokyo Medical University, Japan.
J Dermatol. 2000 Sep;27(9):598-603. doi: 10.1111/j.1346-8138.2000.tb02235.x.
The present report presents two cases of confluent and reticulate papillomatosis. Case 1 was a 24-year-old man who had suffered from skin eruptions for six months, and Case 2 was a 19-year-old woman who had had this disease for three days. In both patients, reticular dark brown papules, accompanied by mild keratosis and infiltration, spread from the trunk to the neck and upper arm. Direct light microscopy did not detect the presence of any fungi, and histopathological examinations confirmed hyperkeratosis, acanthosis, papillomatosis, and mild small-round-cell infiltration. Thus, these patients were diagnosed as confluent and reticulate papillomatosis. Neither one had diabetes or thyroid dysfunction. In Case 1, cefdinir was effective, and in Case 2, minocycline hydrochloride and ketoconazole were effective. To the best of our knowledge, this was the first documented case of confluent and reticulate papillomatosis responding to cefdinir.
本报告介绍了两例融合性网状乳头瘤病。病例1是一名24岁男性，皮肤疹已持续6个月；病例2是一名19岁女性，患病3天。两名患者均出现网状深褐色丘疹，伴有轻度角化和浸润，从躯干蔓延至颈部和上臂。直接光学显微镜检查未发现任何真菌，组织病理学检查证实有角化过度、棘层肥厚、乳头瘤样增生和轻度小圆形细胞浸润。因此，这些患者被诊断为融合性网状乳头瘤病。两人均无糖尿病或甲状腺功能障碍。病例1中，头孢地尼有效；病例2中，盐酸米诺环素和酮康唑有效。据我们所知，这是首例有记录的融合性网状乳头瘤病对头孢地尼有反应的病例。
