Endo M, Kaas J H, Jain N, Smith E L, Chino Y
College of Optometry, University of Houston, Houston, Texas, USA.
Invest Ophthalmol Vis Sci. 2000 Nov;41(12):4022-31.
To better understand the course of cortical maturation during early development, the phenomenon of binocular cross-orientation suppression in neurons of the primary visual cortex (V1) in young infant monkeys was investigated.
Extracellular single-unit recordings were made in anesthetized and paralyzed monkeys ranging in age between 6 days and 8 weeks. Orthogonally oriented, dichoptic sine-wave gratings were used as visual stimuli.
V1 neurons in young infant monkeys showed a higher prevalence and greater magnitude of binocular cross-orientation suppression than in adult monkeys. Binocular suppression decreased and reached an adult level between 4 and 8 weeks of age, the presumed onset-age for stereopsis in monkeys.
During the first 4 weeks of life, the functional connections that are necessary for initiating binocular cross-orientation suppression exist in the monkey primary visual cortex. This finding is consistent with the view that before the abrupt onset of stereopsis, human infants may detect the differences between interocularly iso-oriented gratings and orthogonal gratings.
为了更好地理解早期发育过程中皮质成熟的进程，对幼年猕猴初级视觉皮层（V1）神经元中的双眼交叉取向抑制现象进行了研究。
在年龄为6天至8周的麻醉和麻痹的猕猴中进行细胞外单单位记录。使用正交取向的双眼正弦波光栅作为视觉刺激。
幼年猕猴的V1神经元比成年猕猴表现出更高的双眼交叉取向抑制发生率和更大的抑制幅度。双眼抑制在4至8周龄之间下降并达到成年水平，这是猕猴立体视觉的假定起始年龄。
在生命的前4周，启动双眼交叉取向抑制所需的功能连接存在于猕猴初级视觉皮层中。这一发现与以下观点一致，即在立体视觉突然出现之前，人类婴儿可能能够检测到双眼等取向光栅和正交光栅之间的差异。
